Chalcogen-Nitrogen Bond: Insights into a Key Chemical Motif

Chalcogen-nitrogen chemistry deals with systems in which sulfur, selenium, or tellurium is linked to a nitrogen nucleus. This chemical motif key component of different functional structures, ranging from inorganic materials and polymers, rationally designed catalysts, bioinspired molecules enzymes. The formation selenium–nitrogen bond, typically occurring upon condensation an amine the unstable selenenic acid, often leading intramolecular cyclizations, its disruption, mainly promoted by thiols, are rather common events organic Se-catalyzed processes. In this work, focusing on examples taken selenium biochemistry, bond described, strength reactivity quantified using accurate computational methods applied model molecular systems. intermediate Se–N can be tuned necessity, gives rise significant trends when comparing it stronger S– weaker Te–N bonds, reaffirming also context peculiar valuable role life.